How often is NIDDM complicated with non-diabetic renal disease? An analysis of renal biopsies and the literature.

摘要: According to extensive autopsy studies, non-diabetic renal disease seems be rare in diabetes mellitus, but recent publications suggest a significant prevalence of non-insulin-dependent diabetic (NIDDM) patients, especially the absence retinopathy. The purpose this study was evaluate NIDDM patients biopsies from clinical practice, suspected having disease. In addition we systematically reviewed literature. Biopsies were evaluated at University Department Pathology, Aarhus, Denmark, had been collected several departments nephrology. total 33 consecutive available 1988–1995 (mean age patients: 62 years (range 39–75) known duration 8 1–25); main reason for biopsy proteinuria. Renal function changes ranged slight elevation serum creatinine uraemia. 9 original papers, including our own material 580 examined. On basis careful morphological evaluation according international criteria, no patient exhibited an unequivocal sign glomerular Two strongly not completely convincing evidence glomerulonephritis. One some These 3 also lesions. with end-stage showed interstitial nephropathy without Thus, 4 lesions found. remaining 29 typical diffuse (n = 9) or nodular 20) Twenty simplex literature considerable bias exists towards non-biased materials proteinuria is very similar series. microalbuminuric rare. It can concluded that uncommon even if clinician has suggested other origin. A indication should carefully, and by means routinely performed [Diabetologia (1996) 39: 1638–1645]