Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives.
作者： Nadia Ragab Mohamed , Manal Mohamed Talaat El-Saidi , Yasser Mahmoud Ali , Mohamed Hilmy Elnagdi , None
DOI: 10.1016/J.BMC.2007.06.023
关键词: Stereochemistry 、 Cycloaddition 、 Amidine 、 Chemistry 、 Aldehyde 、 Antibacterial agent 、 Pyrimidine 、 Chemical synthesis 、 Biological activity 、 Imine
摘要: Abstract The condensation of 6-amino-2-thiouracil 1 with aromatic aldehydes afforded azomethine derivatives 3a , b . formed azomethines underwent [4+2] cycloaddition enaminones 4a – c and enaminonitrile 9 to form the corresponding condensed pyrimidines 8a f 11a respectively. On other hand, interaction acetylene 12a 14 pyrido[2,3- d ]pyrimidines 13a 16a newly synthesized 2-azadiene 18 reacted ortho -aminophenol -aminothiophenol 19a yield amidines 21a in vitro antimicrobial activity some compounds was examined. All tested proved be active as antibacterial antifungal agents. Also vivo antitumor 11b 16b against lung (H460) liver (HEPG2) carcinoma cells Compounds showed moderate cell line (H460).
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