S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors
作者： Hsien-Wei Yeh , Tzung-Sheng Lin , Hsiao-Wen Wang , Hou-Wen Cheng , Der-Zen Liu
DOI: 10.1039/C5OB01376C
关键词: Virus inhibitors 、 Virus 、 Phospholipid 、 Hemagglutination assay 、 Liposome 、 Molecular biology 、 Micelle 、 H1N1 influenza 、 Chemistry 、 Cell culture
摘要: An efficient, homogeneous synthesis of phospholipid conjugation S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles liposomes these trisaccharides formed in solution were found to be inhibitors interfering with the entry H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome micelle displayed superior inhibitory activity than 6-sulfate congener both neutralization assay hemagglutination inhibition assay.
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