Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells.

摘要: Abstract Considering the growing knowledge and perspectives on microRNAs (miRNAs) that control high-density lipoprotein cholesterol (HDL-C) levels metabolism, this study aimed at evaluating whether hsa-miR-33a hsa-miR-128a are differentially expressed in peripheral blood mononuclear cells from asymptomatic individuals with low high HDL-C, as well investigating potential relationships ATP binding cassete transporter A1 ( ABCA1 ) expression, efflux capacity other parameters related reverse transport. In addition, associations cardiovascular risk were investigated by carotid-intima media thickness (cIMT). Asymptomatic volunteers of both genders (n = 51) classified according to HDL-C (mg/dL) hypoalphalipoproteinemics (hypo, HDL-C ≤ 39), hyperalphalipoproteinemics (hyper, HDL-C ≥ 68) controls (CTL, HDL-C ≥ 40  ABCG1 when compared CTL. No significant differences efflux, cIMT or plaques found. Further studies necessary elucidate mechanisms underlying complex miRNA network, regulating cellular homeostasis humans its clinical repercussions.