Radiation-Activated Antitumor Vectors

摘要: Radiotherapy (RT) is a primary treatment modality for the majority of solid tumors. The objective to destroy tumor mass by exposure ionizing radiation (IR) from an external beam or isotopic source. IR causes DNA damage directly and indirectly via production reactive oxygen intermediates (ROIs). Accumulation sufficient leads cell death. efficacy RT usually governed dose given, main limitation being need avoid injury surrounding normal tissues. To address latter problem, physical techniques such as conformal intensity-modulated radiotherapy have been developed improve precision delivery volume. However, some tumors prove refractory conventional treatments, insufficient can be delivered tumor. In cases, other therapeutic strategies, chemotherapy, used in combination, particularly if drugs lead increased radiosensitization. Nevertheless, many types, (e.g., glioblastoma) are often resistant even these combined approaches. Consequently, there new strategies that effectiveness current regimens. Gene therapy offers exciting possibility significantly improving without IR-dose escalation undue increases tissue morbidity. Furthermore, potential spatially temporally target activation gene vectors using clinically relevant doses provides attractive prospect.