-8p12-23 and +20q are predictors of subtypes and metastatic pathways in colorectal cancer: construction of tree models using comparative genomic hybridization data.
作者： Xiaobo Li , Jian Chen , Bingjian Lü , Sihua Peng , Richard Desper
关键词: Internal medicine 、 Genetics 、 Colorectal cancer 、 Oncology 、 Tree (data structure) 、 Comparative genomic hybridization 、 Biology
摘要: Abstract A substantial body of evidence suggests the genetic heterogeneous pattern and multiple pathways in colorectal cancer initiation progression. In this study, we construct a branching tree distance-based models to elucidate these patterns by using data set comprised 244 cases comparative genomic hybridization. We identify six most common gains chromosomal regions 7p (37.0%), 7q11–32 (34.8%), 8q (48.3%), 13q (49.1%), 20p (36.1%), 20q (50.4%), nine losses 1p13–36 (30.9%), 4p15 (24.3%), 4q33–34 8p12–23 (50.9%), 15q13–14 (23.5%), 15q24–25 17p 18p (36.5%), 18q (61.7%) cancer. classify into two distinct groups: one preceding with −8p12–23, other +20q. The sample-based classification also demonstrates that can be classified subtypes marked −8p12–23 By comparing chromosomal...
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