Bifunctional transition metal complexes as nucleic acid photoprobes and photoreagents

摘要: Transition metal complexes that bind to DNA have been the focus of extensive research aimed at increasing understanding genetic information processing and developing ways interfere with these mechanisms. Beside continuous development “dark reacting” artificial metallonucleases metal-based chemotherapeutics such as cisplatin, photo-active octahedral successfully used luminescent probes light-driven reactive agents during last decades. A recent emerging trend improve their potential molecular tools for studies material is design bifunctional assemblies where center tethered through a flexible linker nucleic acid recognition or moiety. This mini-review highlights some progresses in derivatization strategies ranging from dimeric chromophore-quencher systems biotin–metal complex conjugates avidin-mediated detection biomolecules.