Aggregation behaviour of biohybrid microgels from elastin-like recombinamers
作者： Smriti Singh , Dan Eugen Demco , Khosrow Rahimi , Radu Fechete , José Carlos Rodriguez-Cabello
DOI: 10.1039/C6SM00954A
关键词: Chemistry 、 Chemical engineering 、 Nuclear magnetic resonance spectroscopy 、 Population 、 Miniemulsion 、 Drug carrier 、 Magic angle 、 Nanotechnology 、 Chemical shift 、 Dynamic light scattering 、 Relaxometry
摘要: Investigation of the aggregation behavior biohybrid microgels, which can potentially be used as drug carriers, is an important topic, because not only causes loss activity, but also toxicity and immunogenicity. To study this effect we synthesized microgels from elastin-like recombinamers (ELRs) using miniemulsion technique. The existence for such at different concentrations temperatures was studied by methods include dynamic light scattering (DLS), (1)H high-resolution magic angle sample spinning (HRMAS) NMR spectroscopy, relaxometry diffusometry. A hysteresis detected in process DLS a function temperature that strongly depends on ELR microgel concentration. further quantitatively analyzed concentration dependence amino-acid residue chemical shifts diffusivity measured population balance kinetic model.
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