Supramolecular Assembly of TPE-Based Glycoclusters with Dicyanomethylene-4H-pyran (DM) Fluorescent Probes Improve Their Properties for Peroxynitrite Sensing and Cell Imaging.
作者： Lei Dong , Mengqi Fu , Lifang Liu , Hai‐Hao Han , Yi Zang
关键词: Fluorescence 、 Chemistry 、 Combinatorial chemistry 、 Peroxynitrite 、 Supramolecular assembly 、 Self-assembly 、 Supramolecular chemistry 、 Tetraphenylethylene 、 Quenching (fluorescence) 、 Pyran
摘要: Two red-emitting dicyanomethylene-4H-pyran (DM) based fluorescent probes were designed and used for peroxynitrite (ONOO- ) detection. Nevertheless, the aggregation-caused quenching effect diminished fluorescence restricted their further applications. To overcome this problem, tetraphenylethylene (TPE) glycoclusters to self-assemble with these DM obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced intensity, leading an selectivity activity of resulting glyco-dot comparing alone in PBS buffer. The glyco-dots also exhibited better results during sensing intracellular ONOO- than alone, thereby offering scope development other similar glyco-systems chemical biological studies.
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