Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

摘要: Inhibition of an initiating oncogene often leads to extensive tumour cell death, a phenomenon known as addiction. This has led the search for compounds that specifically target and inhibit oncogenes anticancer agents. However, there been no systematic exploration whether chromosomal instability generated result deregulation mitotic checkpoint pathway, frequent characteristic solid tumours, any effect on Here we show induction chromosome by overexpression gene Mad2 in mice does not affect regression Kras-driven lung tumours when Kras is inhibited. experience transient consequent recur at markedly elevated rates. The recurrent are highly aneuploid have varied activation pro-proliferative pathways. Thus, early may be responsible relapse after seemingly effective treatments.