Predicting and Overcoming Taxane Chemoresistance.

摘要: Taxanes are microtubule-targeting drugs used as cytotoxic chemotherapy to treat most solid tumors. The development of resistance taxanes is a major cause therapeutic failure and overcoming chemoresistance remains an important challenge improve patient's outcome. Extensive efforts have been made recently identify predictive biomarkers select populations patients who will benefit from taxane-based avoid inefficient treatment with innate resistance. This, together the discovery new mechanisms that include metabolic reprogramming dialogue between tumor its microenvironment, pave way era personalized medicine. In this review, we recapitulate recent insights into taxane present promising emerging strategies overcome in future.