SYMPATHOMIMETIC EFFECTS OF PANCURONIUM BROMIDE ON THE CARDIOVASCULAR SYSTEM OF THE PITHED RAT: A COMPARISON WITH THE EFFECTS OF DRUGS BLOCKING THE NEURONAL UPTAKE OF NORADRENALINE
作者： J.R. DOCHERTY , J.C. McGRATH
DOI: 10.1111/J.1476-5381.1978.TB17321.X
关键词: Norepinephrine 、 Clonidine 、 Sympathectomy 、 Isoprenaline 、 Stimulation 、 Endocrinology 、 Pancuronium bromide 、 Internal medicine 、 Tyramine 、 Chemistry 、 Heart rate
摘要: Abstract 1. The effects of pancuronium bromide on the cardiovascular system pithed rat were examined. Pancuronium had two effects, a short-lasting stimulation following injection and longer-lasting potentiation responses to sympathetic nerve stimulation. 2 initial effect was compared with that tyramine. cardioaccelerator but not pressor both tyramine significantly reduced sympathectomy 6-hydroxydopamine (6-OHDA). 3 action in potentiating known blockers neuronal uptake noradrenaline (NA). (1 mg/kg) cocaine (0.5 potentiated These could be obtained adrenalectomy during neuromuscular blockade gallamine. response NA, tyramine, did affect isoprenaline. or clonidine. 4 Following 6-OHDA, failed potentiate NA. 5 results are discussed relation main pancuronium; an indirect sympathomimetic
sci-hub.se 参考文章(22)
U. Trendelenburg, S. Pluchino, THE INFLUENCE OF DENERVATION AND OF DECENTRALIZATION ON THE ALPHA AND BETA EFFECTS OF ISOPROTERENOL ON THE NICTITATING MEMBRANE OF THE PITHED CAT Journal of Pharmacology and Experimental Therapeutics. ,vol. 163, pp. 257- 265 ,(1968)
John Christie McGrath, The inhibitory and motor innervation of the anococcygeus muscle ProQuest Dissertations & Theses,. ,(1973)
J R Docherty, J C McGrath, Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide [proceedings]. British Journal of Pharmacology. ,vol. 61, ,(1977)
A. J. Coleman, J. W. Downing, W. P. Leary, D. G. Moyes, M. Styles, The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. Anaesthesia. ,vol. 27, pp. 415- 422 ,(1972) , 10.1111/J.1365-2044.1972.TB08247.X
A. D. IVANKOVICH, D. J. MILETICH, R. F. ALBRECHT, B. ZAHED, The effect of pancuronium on myocardial contraction and catecholamine metabolism. Journal of Pharmacy and Pharmacology. ,vol. 27, pp. 837- 841 ,(2011) , 10.1111/J.2042-7158.1975.TB10226.X
R. HUGHES, D.J. CHAPPLE, EFFECTS OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS ON PERIPHERAL AUTONOMIC MECHANISMS IN CATS BJA: British Journal of Anaesthesia. ,vol. 48, pp. 59- 68 ,(1976) , 10.1093/BJA/48.2.59
A.M. Autret, H. Schmitt, S. Fenard, N. Pétillot, Comparison of haemodynamic effects of α-sympathomimetic drugs European Journal of Pharmacology. ,vol. 13, pp. 208- 217 ,(1971) , 10.1016/0014-2999(71)90152-X
A. BARNETT, M. STAUB, S. SYMCHOWICZ, The effect of cocaine and imipramine on tyramine-induced release of noradrenaline-3H from the rat vas deferens in vitro British Journal of Pharmacology. ,vol. 36, pp. 79- 84 ,(1969) , 10.1111/J.1476-5381.1969.TB08305.X
A. S. Clanachan, T. C. Muir, A technique for the study of muscle relaxants by stimulating the spinal motor nerve outflow in the pithed rat British Journal of Pharmacology. ,vol. 46, pp. 514- 516 ,(1972) , 10.1111/J.1476-5381.1972.TB08150.X
J. S. Gillespie, J. C. McGrath, The spinal origin of the motor and inhibitory innervation of the rat anococcygeus muscles The Journal of Physiology. ,vol. 230, pp. 659- 672 ,(1973) , 10.1113/JPHYSIOL.1973.SP010210