Degradation behaviors of three-dimensional hydroxyapatite fibrous scaffolds stabilized by different biodegradable polymers

摘要: Abstract For bone tissue engineering, three-dimensional (3D) macroporous bioceramic scaffolds are usually preferred because they can mimic the inorganic components in natural tissues. Among them, fibrous more due to their biomimetic morphology, while fragile without polymer coating. In this study, hydroxyapatite nanowires (HANW) were prepared using hydrothermal technique and shaped into 3D via steps of dispersing water, freeze-drying sintering. Five biodegradable polymers different features applied coat HANW scaffolds, poly( l -lactide) (PLLA), polycaprolactone (PCL), poly(lactide-co-glycolide) (PLGA), poly(lactide-co-caprolactone) (PLCL) gelatin. By optimzing coating operation, coatings would not deform structure scaffold, cause cytotoxicity. All these could stabilize reinforce scaffold. crystalline PLLA rigid gelatin improve mechanical properties polymer-coated significant than other three polymers. At meantime, or maintain strengths composite alongside degradation for a longer time coatings. summary, proper be helpful obtaining with improved performances targeting engineering.