Prosthetic Joint Infection Due to Rapidly Growing Mycobacteria: Report of 8 Cases and Review of the Literature

摘要: Background Prosthetic joint infection (PJI) due to rapidly growing mycobacteria (RGM) is only occasionally encountered in clinical practice. Therefore, the optimal management for this condition unknown. Methods The medical records of patients who had PJI RGM during 1969-2006 were reviewed summarize its characteristics, treatment, and outcome. Results Eight developed 9 episodes (7 involving knee 1 each hip or elbow) at a median 312 weeks (range, 1-170 weeks) after prosthesis implantation. Patients presented with pain patients), swelling fever (3 accompanied by an elevated erythrocyte sedimentation rate (median, 70.5 mm/h) C-reactive protein level 6 mg/dL). Mycobacterium chelonae (n=3), abscessus (n=2), fortuitum smegmatis (n=1) isolated from infected joints. Seven prostheses resected, whereas 2 retained surgical debridement. Six 8 received > = active antimicrobial agent least months. During follow-up period 33 2.6-326 intervention, no microbiological relapses observed. Reimplantation was performed successfully underwent resection arthroplasty. continued receive prolonged courses suppressive therapy. Conclusions rare cause that should be suspected negative results routine bacterial cultures. combination arthroplasty therapy preferred approach. However, cases prosthetic components, may suppressed lifelong effective antibiotic