Role of testicular macrophages in the response of Leydig cells to gonadotrophins in young hypophysectomized rats.

摘要: The Leydig cells of young hypophysectomized rats are highly sensitive to the stimulatory effects exogenous pituitary hormones. aim this study was analyse role testicular macrophages in response different Male were at 28 days age and 10 later they injected intratesticularly with dichloromethylene diphosphonate-containing liposomes (right testis) deplete macrophages, 0.9% NaCl (left testis). One week later, animals treated daily 1 IU rat GH (rGH)/rat, 5 recombinant human FSH (recFSH)/rat, chorionic gonadotrophin (hCG)/rat, or vehicle for 7 days. killed on day after last injection. rGH showed increased body weight number size left testes, but no significant found. Treatment recFSH induced a increase tubular diameter both testes. In increased; not changed, although significantly cross-sectional area. This effect abolished right (macrophage-depleted) However, growth seminiferous tubules modified by absence macrophages. Rats hCG serum testosterone levels, as well an ventral prostate. increased. Otherwise, unchanged whereas partially abolished. These data indicate that needed treatment.