作者: Yanmin Xu , Ji Huang , Leina Ma , Juanjuan Shan , Junjie Shen
DOI: 10.1016/J.CANLET.2015.11.034
关键词: Transfection 、 Signal transduction 、 Cancer research 、 Apoptosis 、 Chemistry 、 Sorafenib 、 Hepatocellular carcinoma 、 MiR-122 、 Growth factor 、 microRNA 、 Pharmacology
摘要: … To elucidate the molecular mechanisms underlying acquired resistance to sorafenib, we analyzed the effect of sorafenib on activation of IGF-1R and the downstream RAS/RAF/ERK …