MicroRNA-122 confers sorafenib resistance to hepatocellular carcinoma cells by targeting IGF-1R to regulate RAS/RAF/ERK signaling pathways.

作者: Yanmin Xu , Ji Huang , Leina Ma , Juanjuan Shan , Junjie Shen

DOI: 10.1016/J.CANLET.2015.11.034

关键词: TransfectionSignal transductionCancer researchApoptosisChemistrySorafenibHepatocellular carcinomaMiR-122Growth factormicroRNAPharmacology

摘要: … To elucidate the molecular mechanisms underlying acquired resistance to sorafenib, we analyzed the effect of sorafenib on activation of IGF-1R and the downstream RAS/RAF/ERK …

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