Myocarditis and idiopathic dilated cardiomyopathy

摘要: Idiopathic dilated cardiomyopathy (IDC) accounts for 25% of cases heart failure in the United States. Understanding relationship between an inciting event or agent and development IDC has progressed only recently. Once developed, treatment is palliative little can be done to alter natural course disease. Active myocarditis, a suspected precursor IDC, myocardial inflammation injury without ischemia. The disease ranges from self-limited flulike illness one serious consequence with arrhythmias, failure, death. Many agents have been associated clinical manifestations depend on interplay host response. murine model expanded use endomyocardial biopsy using Dallas criteria increased our understanding myocarditis its sequelae. Therapy consists managing symptoms conventional medical regimens failure. Immunosuppressive therapy should reserved patients biopsy-proven who failed therapy. Continued deterioration warrants ventricular assistance consideration cardiac transplantation.