High-dose Chemotherapy of Small-Cell Lung Cancer With and Without Bone Marrow Transplantation

摘要: The administration of active combination chemotherapy has resulted in a major advance the treatment small-cell lung cancer (SCLC) [1,2]. Chemotherapy not only induces frequent objective response rates between 75% and 95%, but also prolongs survival significantly. However, minority patients cna be considered as cured [3–5]. five-year overall rate is about 5–10% there are 10 times more long-term survivors among with limited disease than those disseminated cancer. Various attempts have been proposed to improve these results [6]: new drugs, development consolidation and/or maintenance treatments, use intensive regimens, alternating or sequential combinations chemotherapy, adjuvant thoracic irradiation surgery, effective prevention central nervous system relapses. Among approaches, particularly appealing, although it may result higher toxicity.