Resistance in the Post-Genomics Age

摘要: This chapter reviews what is known about insect resistance in a select group of classic pesticide classes and then discusses some exciting new possibilities that “ Omics ” may provide for the near future. The potential importance understanding molecular mechanism by which insects resist environmental challenges also discussed. An “Achilles' heel trait” as target molecule that, when inhibited (or negatively impacted), reduces ability an organism or population organisms to persist specific condition challenge has been defined. Examples are illustrated use evolutionarily conserved mechanisms common all animals (e.g., aspects oxidative stress) well those particular peritrophic membrane digestive system). Finally, we have how revolution just beginning reveal more in-depth knowledge system-wide bases these metabolic resistance). Perhaps not surprising, but none less exciting, emerging examples involvement hitherto unidentified genes involved resistance. These findings should allow us identify novel safe pesticides better design management strategies ensure their long-term utility.