The reaction of ferrous leghemoglobin with hydrogen peroxide to form leghemoglobin(IV).
作者： I Aviram , J B Wittenberg , A Wittenberg
DOI: 10.1016/S0021-9258(17)30321-6
关键词: Ferrous 、 Dithionite 、 Leghemoglobin 、 Oxidation state 、 Polymer chemistry 、 Titration 、 Ferric 、 Chemistry 、 Inorganic chemistry 、 Hydrogen peroxide 、 Second order kinetics
摘要: Ferrous leghemoglobin reacts with hydrogen peroxide to form the stable product, leghemoglobin(IV). The reaction follows second order kinetics (k = 2.24 X 10(4) M-1 S-1 at 20 degrees C) and may be regarded as a single-step, two-electron oxidation. Ferric is not an intermediate. oxidation state of leghemoglobin(IV) established by reductive titration dithionite; 2 eq dithionite are required convert 1 mol ferrous leghemoglobin. An outstanding property its stability, little change noted after 12 h 25 C. Leghemoglobin(IV) differs from higher states other hemoglobins myoglobins in that it does react oxygenated protein.
sci-hub.st 参考文章(33)
Karl A. Schellenberg, Leslie Hellerman, OXIDATION OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE Journal of Biological Chemistry. ,vol. 231, pp. 547- 556 ,(1958) , 10.1016/S0021-9258(19)77327-X
P. George, D. H. Irvine, A possible structure for the higher oxidation state of metmyoglobin Biochemical Journal. ,vol. 60, pp. 596- 604 ,(1955) , 10.1042/BJ0600596
Beatrice A. Wittenberg, Jonathan B. Wittenberg, Robert W. Noble, The Reaction of Ferrous Ascaris Perienteric Fluid Hemoglobin with Hydrogen Peroxide Journal of Biological Chemistry. ,vol. 247, pp. 4008- 4013 ,(1972) , 10.1016/S0021-9258(19)45132-6
Takashi Yonetani, Heinz Schleyer, Studies on Cytochrome c Peroxidase IX. THE REACTION OF FERRIMYOGLOBIN WITH HYDROPEROXIDES AND A COMPARISON OF PEROXIDE-INDUCED COMPOUNDS OF FERRIMYOGLOBIN AND CYTOCHROME c PEROXIDASE Journal of Biological Chemistry. ,vol. 242, pp. 1974- 1979 ,(1967) , 10.1016/S0021-9258(18)96096-5
J Peisach, W E Blumberg, B A Wittenberg, J B Wittenberg, The Electronic Structure of Protoheme Proteins: III. CONFIGURATION OF THE HEME AND ITS LIGANDS Journal of Biological Chemistry. ,vol. 243, pp. 1871- 1880 ,(1968) , 10.1016/S0021-9258(18)93522-2
Cyril A. Appleby, Beatrice A. Wittenberg, Jonathan B. Wittenberg, Leghemoglobin II. CHANGES IN CONFORMATION AND CHEMICAL REACTIVITY LINKED TO REACTION WITH A DISSOCIABLE LOW MOLECULAR WEIGHT LIGAND, X Journal of Biological Chemistry. ,vol. 248, pp. 3183- 3187 ,(1973) , 10.1016/S0021-9258(19)44025-8
Jay A. Berzofsky, J. Peisach, W.E. Blumberg, Sulfheme Proteins Journal of Biological Chemistry. ,vol. 246, pp. 3367- 3377 ,(1971) , 10.1016/S0021-9258(18)62234-3
Jonathan B. Wittenberg, Cyril A. Appleby, Beatrice A. Wittenberg, The Kinetics of the Reactions of Leghemoglobin with Oxygen and Carbon Monoxide Journal of Biological Chemistry. ,vol. 247, pp. 527- 531 ,(1972) , 10.1016/S0021-9258(19)45734-7
J B Wittenberg, Leghemoglobin. Low temperature optical spectra of acid and alkaline forms of leghemoglobin(IV). Configuration of the heme. Journal of Biological Chemistry. ,vol. 253, pp. 5690- 5693 ,(1978) , 10.1016/S0021-9258(17)30322-8
C A Appleby, W E Blumberg, J Peisach, B A Wittenberg, J B Wittenberg, Leghemoglobin. An electron paramagnetic resonance and optical spectral study of the free protein and its complexes with nicotinate and acetate. Journal of Biological Chemistry. ,vol. 251, pp. 6090- 6096 ,(1976) , 10.1016/S0021-9258(17)33063-6