Enzyme-linked immunosorbent assay for antibodies against teichoic acid in patients with staphylococcal infections.

摘要: A highly purified teichoic acid preparation was used in an enzyme-linked immunosorbent assay to measure the specific immunoglobulin G (IgG) and IgM response staphylococcal disease. Antibody determination a normal population, showing difference of up 20-fold mean IgG titers between youngest children adults, establish age-correlated upper values. antibodies were found be little diagnostic value since their often low or absent. Increased 24 27 (89%) patients with endocarditis, 11 14 (79%) complicated septicemia, 10 20 (50%) uncomplicated septicemia serum samples drawn days 7 30 With paired samples, numbers increased 17 17, 3 4, 6 7, respectively, same patient groups. less demonstrated chronic osteomyelitis (7 22). The for sensitive method diagnosing endocarditis septicemia. For optimal results, both substantial variation importance adequately spaced should considered.