Effect of diets high in omega-3 and omega-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis.

摘要: Abstract The effect of dietary menhaden oil containing ω-3 fatty acids and corn rich in ω-6 fed during the initiation and/or postinitiation stages colon carcinogenesis was investigated male F344 rats. At 5 weeks age, all animals were divided into seven groups (39 rats/group) semipurified diets 5% (LCO), 23.5% (HCO), or 18.5% plus (HFO). 7 except vehicle (normal saline)-treated given two weekly s.c. injections azoxymethane (AOM) at a dose rate 15 mg/kg body weight, once weekly. Three days after second injection AOM, LCO, HCO, HFO, HFO transferred, respectively, to continued on these until termination experiment. All necropsied 42 carcinogen treatment. Body weights various experimental periods comparable. As expected, HCO diet period significantly increased AOM-induced incidence multiplicity adenocarcinomas, whereas phase had no effect. Colon tumor reduced either phases as compared with those diet. Whereas precise mechanism producing difference between high (HFO) (HCO) remain be elucidated, it is likely that may due alteration metabolism modulation prostaglandin synthesis, respectively.