The efficacy and safety of multiple-dose intravenous tranexamic acid on blood loss following total knee arthroplasty: a randomized controlled trial
作者： Yiting Lei , Jinwei Xie , Bin Xu , Xiaowei Xie , Qiang Huang
DOI: 10.1007/S00264-017-3519-X
关键词: Tranexamic acid 、 Bolus (medicine) 、 Stroke 、 Surgery 、 Fibrinolysis 、 Orthopedic surgery 、 Randomized controlled trial 、 Medicine 、 Group B 、 Fibrin
摘要: To explore the efficacy and safety of multiple-dose oral tranexamic acid (TXA) on blood loss following primary total hip arthroplasty (THA). A 152 patients were randomized into three groups to receive 2 g TXA two hours pre-operatively (group A), or another bolus four hours post-operatively B), boluses four, ten, 16 C). The outcomes (TBL), hidden (HBL), transfusion rate. secondary haemoglobin (Hb) haematocrit (Hct) drop, level fibrinolysis parameters (fibrin degradation products, D-dimer), complications (thrombotic diseases, stroke, cardiac infarction, infection). mean TBL HBL in group C lower than those (p 0.05). Multiple could further reduce loss, Hb Hct restrain post-operative THA without increasing risk complications. Therapeutic study.
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