Liposome-containing preparation and process for producing the same

摘要: Preparations containing liposomes having a water soluble medicine efficiently encapsulated therein are provided through process for producing liposome-containing preparations, comprising: (i) the first step of mixing liposome membrane constituting components with supercritical carbon dioxide in pressure vessel at 32° to 65°C thereby obtain suspension; (ii) second adding an aqueous solution suspension and them together; (iii) third depressurizing interior so as discharge dioxide, obtaining base dispersion therein; (iv) fourth subsequent step, filtering static extruder equipped filter 0.1 1 μm pore diameter attain particle regulation into 0.05 0.8 average diameter, wherein after or is subjected ultrafiltration concentrate same.