C/EBPß Isoform Specific Gene Regulation: It's a Lot more Complicated than you Think!

摘要: It has been almost 30 years since C/EBPs was discovered. Seminal studies have shown that is a master regulator of mammary gland development and to control influence proliferation differentiation through varying mechanisms. The single-exon mRNA yields at least three different protein isoforms which diverse, specific, context-dependent, often non-overlapping roles throughout breast cancer progression. These are dictated by number complex factors including: expression levels other C/EBP family members their stoichiometry relative the isoform in question, binding site affinity, post-translational modifications, co-factor expression, even hormone lactogenic status. Here we summarize historical work up latest findings field on cancer. With current emphasis improving immunotherapy role specific regulating chemokine cytokine immune microenvironment will be increasing interest.