Callosal damage and cognitive deficits in chronic carbon monoxide intoxication: A diffusion tensor imaging study

摘要: Abstract Purpose To evaluate the correlation between microstructural damage in corpus callosum (CC) and cognitive performance of patients with or without delayed encephalopathy (DE) after carbon monoxide (CO) intoxication chronic stage. Methods Diffusion tensor imaging (DTI) was performed more than 6 months CO for 10 DE recruited from out-patient clinics, as well 15 normal controls (NCs). Using a probabilistic tractography method to parcel CC based on fiber projections cortical connectivity patterns, DTI indices were calculated subregions further correlated performance. Results The group exhibited significantly lower fractional anisotropy (FA) higher radial diffusivity (RD) values prefrontal, premotor, primary motor, sensory, parietal, occipital did NCs. also FA prefrontal premotor non-DE group. Lower RD associated poorer scores symbol search test. Conclusions may cause subregions, subsequent impairment. This finding suggests that selective is profound DE.