Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

摘要: More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical pathological significance ROS1 expression in intrahepatic cholangiocarcinoma. One hundred ninety-four patients with curatively resected were included this study. Tumor tissue specimens collected analyzed for gene rearrangement using fluorescence situ hybridization (FISH) protein immunohistochemistry (IHC). was positive (moderate or strong staining) 72 tumors (37.1 %). significantly correlated well differentiated tumors, papillary mucinous histology, oncocytic/hepatoid intestinal type periductal infiltrating intraductal growing (vs. mass-forming cholangiocarcinoma). ROS-expressing associated better disease-free survival (30.1 months (+) vs. 9.0 months (−) p = 0.006). Moreover, an independent predictor a multivariate analysis (HR 0.607, 95 % CI 0.377–0.976; p = 0.039). Although break-apart FISH successfully performed 102 samples, split pattern indicative not found examined samples. well-differentiated histology our by