Dioxindole in asymmetric catalytic synthesis: direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes.
作者： Michele Retini , Giulia Bergonzini , Paolo Melchiorre
DOI: 10.1039/C2CC30198A
关键词: Bifunctional 、 Michael reaction 、 Primary (chemistry) 、 Chemistry 、 Catalysis 、 Organic chemistry
摘要: The asymmetric Michael addition of dioxindoles to β-substituted nitroalkenes is reported. bifunctional primary amine-thiourea A, by means a non-covalent-based mode catalysis, secures direct access 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol.
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