Detection Of Chemical And Biological Agents Using Oligonucleotide Aptamers
作者： Adam J. Lowe
DOI:
关键词: Molecular biology 、 Duplex (building) 、 Aptamer 、 Oligonucleotide 、 Biology 、 Combinatorial chemistry 、 Binding domain 、 Molecule
摘要: Methods and systems for detecting chemical biological agents using oligonucleotide aptamers. A sensor includes a detection complex between an aptamer that has binding domain the or agent, first with sequence complementary to region of aptamer. In absence form intermediate combination. presence combination dissociates. The further second interacts duplex structure only when is dissociated from When formed, it can interact reporter molecule which in turn initiates signal reporting agent.
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