Functionalized α,α-Dibromo Esters through Claisen Rearrangements of Dibromoketene Acetals
作者： Nathan J. Dupper , Ohyun Kwon
DOI: 10.1021/ACS.ORGLETT.5B00209
关键词: Chemistry 、 Tandem 、 Selectivity 、 Acetal 、 Stereoisomerism 、 Molecule 、 Allylic rearrangement 、 Organic chemistry 、 Claisen rearrangement
摘要: Allylic alcohols can be transformed into γ,δ-unsaturated α,α-dibromo esters through a two-step process: formation of bromal-derived mixed acetal, followed by tandem dehydrobromination/Claisen rearrangement. The scope and selectivity both steps have been investigated. product were subjected to various carbon–carbon bond-forming reactions, oxidations, lactonizations.
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