Microfluidic device and method for detecting rare cells
作者： Max S. Wicha , Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Lianette Rivera Baez
DOI:
关键词: Communication channel 、 Acoustics 、 Microfluidics 、 Rare cell 、 Lift (force) 、 Sample (graphics) 、 Engineering drawing 、 Inlet 、 Materials science
摘要: A microfluidic device for detecting rare cells in a fluid sample comprises the cell and other cells. The an inlet receiving sample, labyrinth channel structure communication with inlet, outlet collecting separated from sample. at least one through which flows. has plurality of segments corners each corner defined between adjacent segments. presence induces separation as move to first equilibrium position within when ratio inertial lift forces (F Z ) Dean flow D is 2 10.
lens.org 参考文章(212)
Sunitha Nagrath, Lecia V. Sequist, Shyamala Maheswaran, Daphne W. Bell, Daniel Irimia, Lindsey Ulkus, Matthew R. Smith, Eunice L. Kwak, Subba Digumarthy, Alona Muzikansky, Paula Ryan, Ulysses J. Balis, Ronald G. Tompkins, Daniel A. Haber, Mehmet Toner, Isolation of rare circulating tumour cells in cancer patients by microchip technology Nature. ,vol. 450, pp. 1235- 1239 ,(2007) , 10.1038/NATURE06385
Yun-Fan Sun, Xin-Rong Yang, Jian Zhou, Shuang-Jian Qiu, Jia Fan, Yang Xu, Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance Journal of Cancer Research and Clinical Oncology. ,vol. 137, pp. 1151- 1173 ,(2011) , 10.1007/S00432-011-0988-Y
Patrizia Paterlini-Brechot, Naoual Linda Benali, Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Letters. ,vol. 253, pp. 180- 204 ,(2007) , 10.1016/J.CANLET.2006.12.014
Nanda Gopal Sahoo, Hongqian Bao, Yongzheng Pan, Mintu Pal, Mitali Kakran, Henry Kuo Feng Cheng, Lin Li, Lay Poh Tan, Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study Chemical Communications. ,vol. 47, pp. 5235- 5237 ,(2011) , 10.1039/C1CC00075F
Zunfu Ke, Millicent Lin, Jie-Fu Chen, Jin-sil Choi, Yang Zhang, Anna Fong, An-Jou Liang, Shang-Fu Chen, Qingyu Li, Wenfeng Fang, Pingshan Zhang, Mitch A. Garcia, Tom Lee, Min Song, Hsing-An Lin, Haichao Zhao, Shyh-Chyang Luo, Shuang Hou, Hsiao-hua Yu, Hsian-Rong Tseng, Programming thermoresponsiveness of NanoVelcro substrates enables effective purification of circulating tumor cells in lung cancer patients. ACS Nano. ,vol. 9, pp. 62- 70 ,(2015) , 10.1021/NN5056282
Mahaveer D. Kurkuri, Fares Al-Ejeh, Jun Yan Shi, Dennis Palms, Clive Prestidge, Hans J. Griesser, Michael P. Brown, Benjamin Thierry, Plasma functionalized PDMS microfluidic chips: towards point-of-care capture of circulating tumor cells Journal of Materials Chemistry. ,vol. 21, pp. 8841- 8848 ,(2011) , 10.1039/C1JM10317B
Mirko Nitschke, Stefan Gramm, Thomas Götze, Monika Valtink, Juliane Drichel, Brigitte Voit, Katrin Engelmann, Carsten Werner, Thermo-responsive poly(NiPAAm-co-DEGMA) substrates for gentle harvest of human corneal endothelial cell sheets Journal of Biomedical Materials Research Part A. ,vol. 80, pp. 1003- 1010 ,(2007) , 10.1002/JBM.A.31098
Klaus Pantel, Ruud H. Brakenhoff, Burkhard Brandt, Detection, clinical relevance and specific biological properties of disseminating tumour cells Nature Reviews Cancer. ,vol. 8, pp. 329- 340 ,(2008) , 10.1038/NRC2375
Chi Wu, Huaijie Hao, Longyun Li, Xiaoyun Zhou, Zijian Guo, Li Zhang, Xiaotong Zhang, Wei Zhong, Huiqin Guo, Ross Macrae Bremner, Ping Lin, Preliminary Investigation of the Clinical Significance of Detecting Circulating Tumor Cells Enriched from Lung Cancer Patients Journal of Thoracic Oncology. ,vol. 4, pp. 30- 36 ,(2009) , 10.1097/JTO.0B013E3181914125
Sukant Mittal, Ian Y. Wong, William M. Deen, Mehmet Toner, Antibody-functionalized fluid-permeable surfaces for rolling cell capture at high flow rates. Biophysical Journal. ,vol. 102, pp. 721- 730 ,(2012) , 10.1016/J.BPJ.2011.12.044