Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.

摘要: Conventional MRI implicitly treats the proton signal as a single, narrow Lorentzian. However, water signals in vivo are often inhomogeneously broadened and have multiple resolvable components. These components represent discrete populations of molecules within each pixel which affected differently by physiology contrast agents. Accurate measurement component resonance can improve anatomic functional MR images provide insight into structure dynamics subpixelar microenvironments. This report describes high spectral spatial resolution (HiSS) imaging rodent prostate tumors before after injection superparamagnetic agent. HiSS datasets were used to synthesize intensity is proportional peak height, frequency, linewidth. showed features not clearly delineated conventional T2 gradient echo images. obtained agent T *2 T1 changes seen associated with microvessel density permeability. The results suggest agents has potential characterization tumors. Magn Reson Med 43:633–639, 2000. © 2000 Wiley-Liss, Inc.