Guidance Cues in the Developing Brain

摘要: Complex Patterns and Simple Architects: Molecular Guidance Cues for Developing Axonal Pathways in the Telencephalon.- 1 Introduction.- 2 The Four Major Classes of Are Netrins, Semaphorins, Slits, Ephrins.- 2.1 Netrins Usually Function as Chemoattractants Bind to Deleted Colorectal Cancer Neogenin.- 2.2 Semaphorins Act Chemorepellents Most Some Axons Neuropilins, Plexins, L1.- 2.3 Slits Midline Repellents That Robo Receptors.- 2.4 Ephrins Eph Receptor Tyrosine Kinases Involved Bidirectional Signaling.- 3 Display a Characteristic Spatio-Temporal Pattern Expression Embryonic Fetal Zones 3.1 Proliferative Zones: Ventricular Zone, Subventricular Ganglionic Eminence.- 3.2 Intermediate Zone: Zone Neuronal Migration Growth.- 3.3 Subplate Marginal Sites Earliest Synaptogenesis Between "Waiting" Transient Populations Cells.- 3.4 Cortical Plate: Primordium Future Layers II-VI.- 4 Have Complementary and/or Overlapping Roles Establishment Specific Pathways.- 4.1 Commisural Pathways: Corpus Callosum, Anterior Commisure, Hippocampal Commisure.- 4.2 Thalamocortical Corticothalamic 4.3 Corticofugal 4.4 Ascending Monoaminergic 4.5 Afferent, Efferent Intrinsic Formation.- 4.6 Olfactory System.- 5 Early Genes Regionalization Areal Specification Cerebral Cortex Can Regulate Cues.- 6 Discussion Conclusions.- References.- Phosphorylation tau Associated with Distinct Changes Growth Cone Cytoskeleton.- Historical Note.- Cytoskeleton Microtubule-Associated Proteins.- Composition Translocation.- Gene Organization Regulation.- Structure Post-Translational Modifications 7 Subcellular Localization tau.- 8 Role Polarity.- 9 Outgrowth Morphology.- Developmental Possible Gangliosides Brain Development.- Neural Induction Tube Proliferation Glial Progenitor Neurogenesis Neuron Migration.- Fibre Tract Mapping, Dentritogenesis, Apoptosis.- 2.5 Myelination.- 2.6 Structural Functional Maturation.- 2.7 Aging Degeneration.- Nervous Mannose-Binding Lectins Cerebrum Evidence Presence Central System Lectins.- Ontogenetic Variations Glycoconjugates During Degradation Accumulated Mannose-Rich Glycoproteins Target Neurones.- Cerebrum.- Cerebellar Soluble 5.1 Lectin Contact Neurone 5.2 Myelination Processes.- R1.- 6.1 Interleukin-2 Oligodendrocyte Proliferation.- Conclusions Perspective.- Motility.- Cell Guided Radial Tangential Neurite Outgrowth.- Conclusion Perspectives.- Myelin Molecules Limiting Plasticity.- Nogo.- Myelin-Associated Glycoprotein.- Chondroitin Sulfate Proteoglycans.- Vaccine.- Signaling Inhibition Nerve Regeneration.- Concluding Remarks.- References.