Analysis of mechanical properties of cancellous bone under conditions of simulated bone atrophy

摘要: Abstract The mechanical properties of cancellous bone have been shown to depend on density and the anisotropy trabecular structure. By means high-resolution quantitative computed tomography (QCT), providing a nominal resolution 0.17 mm, it became possible assess both apparent microstructure intact bones. In order study influence age- disease-related loss bone, more phenomenological approach was used develop novel resorption algorithm, called simulated atrophy. which is principlally based constrained Gauss filtration segmented data volumes, applied create derived microstructural models. behavior can be expressed as function anisotropic model continuum level. To atrophy strength we compared three models: originally noninvasively measured biopsy two models simulating moderate pronounced For comparison models, Young's moduli in orthogonal directions were predicted for each with help three-dimensional finite-element analysis. Realistic results found tissue chosen. siggest that prediction material noninvasive measurements microstructures application may helpful understand strength.