Immunohistochemical observations of cellular differentiation and proliferation in endochondral bone formation from grafted periosteum: expression and localization of BMP-2 and -4 in the grafted periosteum.
作者： Takaaki Ueno , Toshimasa Kagawa , Miwa Kanou , Takashi Fujii , Joji Fukunaga
DOI: 10.1016/J.JCMS.2003.07.006
关键词: Anatomy 、 Bone cell 、 Medicine 、 Bone morphogenetic protein 7 、 Periosteum 、 Intramembranous ossification 、 Bone healing 、 Endochondral ossification 、 Cell biology 、 Chondrogenesis 、 Bone morphogenetic protein 2
摘要: Abstract Purpose: To clarify the involvement of bone morphogenetic proteins (BMPs) in proliferation and differentiation osteo/chondrogenic cells during process formation from grafted periosteum. Material Methods: Tibial periosteum young Japanese white rabbits was into suprahyoid muscles removed after 7, 9, 14 or 21 days. BMP-2, -4, proliferative cell nucleus antigen (PCNA) immunoreaction Alcian blue staining then sought microscopically. Results: PCNA positive expressed BMP-2 at 7 These differentiated chondroblasts that 9 After days, cartilage seen, -4 expressions were observed mature hypertrophic chondrocytes. Endochondral ossification days osteoblasts showed both expression. Conclusion: Both appear to play regulatory roles endochondral periosteum, due their chondrogenic osteogenic cells.
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