Outcome and predictors of treatment failure in early post-surgical prosthetic joint infections due to Staphylococcus aureus treated with debridement

摘要: Abstract Experience with debridement and prosthesis retention in early prosthetic joint infections (PJI) due to Staphylococcus aureus is scarce. The present study aimed evaluate the outcome predictors of failure. Patients prospectively registered an PJI S. 2 years follow-up were reviewed. Demographics, co-morbidity, type implant, clinical manifestations, surgical treatment, antimicrobial therapy recorded. Remission was defined when patient had no symptoms infection, retained C-reactive protein (CRP) ≤1 mg/dL. Univariate multivariate analysis performed. Fifty-three patients a mean ± SD age 70 10.8 Thirty-five on knee 18 hip prosthesis. duration intravenous oral antibiotics 10.6 6.7 88 45.9 days, respectively. After follow-up, 40 (75.5%) remission. Variables independently associated failure need for second (OR 20.4, 95% CI 2.3–166.6, p 0.006) CRP > 22 mg/dL 9.8, 1.5–62.5, 0.01). onset infection within 25 days after arthroplasty at limit significance 8.3, 0.8–85.6, 0.07). Debridement followed by short period reasonable treatment option aureus. Predictors control first arthroplasty.