PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling

摘要: The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development a novel therapeutic option against representative that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. Peroxisome proliferator-activated receptor α (PPARα), member steroid/nuclear superfamily, is known perform various physiological functions. Recently, we reported PPARα in activated cells exerted anti-inflammatory effects deficiency resulted high susceptibility glomerulonephritis. To investigate whether activation improves activity MsPGN, examined protective agonist, clofibrate, well-established model human anti-Thy1 nephritis, for first time. This study demonstrated pretreatment with clofibrate (via 0.02% or 0.1% clofibrate-containing diet) continuously glomerular PPARα, which outweighed deterioration associated nephritic process. appeared suppress NF-κB signaling pathway glomeruli by induction IκBα, resulting reduction proteinuria amelioration active inflammatory pathologic changes. These findings suggest antinephritic potential PPARα-related medicines MsPGN. might useful as treatment CKD.