Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

作者: B M Madhok , S Yeluri , S L Perry , T A Hughes , D G Jayne

DOI: 10.1038/SJ.BJC.6605701

关键词: Citric acid cycleCancerInternal medicineBiologyEndocrinologyCancer researchPyruvate kinaseCancer cellPyruvate dehydrogenase kinasep53 upregulated modulator of apoptosisPyruvate dehydrogenase complexMetastasis

摘要: … with DCA inhibited cellular proliferation and whether there … non-cancerous cells through all stages of the cell cycle, without … that DCA induced G 2 arrest in colorectal cancer cells. This is …

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