Fatigue is cross-sectionally not associated with objective assessments of inflammation, but changes in fatigue are associated with changes of disease activity assessments during biologic treatment of patients with established rheumatoid arthritis.

摘要: The associations between fatigue and disease activity in patients with rheumatoid arthritis (RA) have not been defined. present objectives were to explore RA the cross-sectional longitudinal relation of subjective as well objective assessments activity. consecutively included when initiating biologic disease-modifying anti-rheumatic drugs (DMARDs) assessed at baseline, 1, 2, 3, 6, 12 months investigation fatigue, patient-reported outcome measures (PROMs; joint pain patient’s global activity, MHAQ, catastrophizing, Mental Health score), clinical examinations (examiner’s 28 tender swollen counts), laboratory variables (ESR, CRP, calprotectin). Ultrasound (semi-quantitative scoring (0–3)) grey scale power Doppler performed 36 joints 4 tendons. Statistics one-way analysis variance, Pearson’s correlations, multiple linear logistic regression analysis. A total 208 (mean (SD) age 53.2 (13.2) years, duration 9.8 (8.5) years) included. Fatigue levels diminished during follow-up baseline/12 months; 4.8 (2.8)/3.0 (2.5) (p < 0.001)). Substantial correlations cross-sectionally found PROMs (median (IQR) r=0.61 (0.52-0.71)) but inflammatory assessments. During follow-up, baseline was associated 0.001) However, change all variables. Higher lower composite score remission rates. treatment Anzctr.org.au identifier ACTRN12610000284066, Norwegian Regional Committee for Medical Research Ethics South East reference number 2009/1254