Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
作者： M. Jain , R. Nilsson , S. Sharma , N. Madhusudhan , T. Kitami
关键词: Metabolic pathway 、 Gene expression profiling 、 Glycine 、 Cancer 、 Cell cycle 、 Biology 、 Biochemistry 、 Cell biology 、 Cancer cell 、 Mitochondrion 、 Cell growth
摘要: Metabolic reprogramming has been proposed to be a hallmark of cancer, yet systematic characterization the metabolic pathways active in transformed cells is currently lacking. Using mass spectrometry, we measured consumption and release (CORE) profiles 219 metabolites from media across NCI-60 cancer cell lines, integrated these data with preexisting atlas gene expression. This analysis identified glycine expression mitochondrial biosynthetic pathway as strongly correlated rates proliferation cells. Antagonizing uptake its biosynthesis preferentially impaired rapidly proliferating Moreover, higher this was associated greater mortality breast patients. Increased reliance on may represent vulnerability for selectively targeting rapid proliferation.
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