An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.
作者： Peiyuan Wang , Byoung-Kwon Chun , Suguna Rachakonda , Jinfa Du , Noshena Khan
DOI: 10.1021/JO901345J
关键词: Stereoselectivity 、 Enzyme inhibitor 、 Regioselectivity 、 Prodrug 、 Stereocenter 、 Stereochemistry 、 Chemical synthesis 、 PSI-6130 、 Nucleophilic substitution 、 Chemistry
摘要: R7128 is the prodrug of 2′-deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130), a potent and selective inhibitor of HCV NS5B polymerase. Currently, R7128 is in clinical trials for the …
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