PYRIMIDINE BIOSYNTHESIS AND ITS REGULATION IN THE DEVELOPING RAT BRAIN1
作者： M. E. Weichsel , L. Dawson
DOI: 10.1111/J.1471-4159.1976.TB04436.X
关键词: Orotic acid 、 Uridine 、 Purine 、 RNA 、 Pyrimidine metabolism 、 Biology 、 Biosynthesis 、 Selective inhibition 、 Rat brain 、 Biochemistry
摘要: —Measurements of the incorporation [14C]NaHCO3 into orotic acid, uridine nucleotides and RNA in tissue minces establish occurrence complete orotate pathway for de novo biosynthesis pyrimidines rat brain. Selective inhibition various radiolabelled precursors acid by demonstrates operation a feedback control mechanism brain indicates carbamoylphosphate synthetase to be site inhibition; purine nucleosides were similarly found inhibit pyrimidines. The activity pathway, as assessed rate was very high fetal decline rapidly with neurological development; mature exhibits less than 1% at 18 days gestation. Comparative studies on ability several extraneural tissues utilize [14C]aspartate lead us speculate that variations synthesize are determined similar their carbamoylphosphate.
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