STAT5b as molecular target in pancreatic cancer--inhibition of tumor growth, angiogenesis, and metastases.

摘要: The prognosis of patients suffering from pancreatic cancer is still poor and novel therapeutic options are urgently needed. Recently, the transcription factor signal transducer activator 5b (STAT5b) was associated with tumor progression in human solid cancer. Hence, we assessed whether STAT5b might serve as an anticancer target ductal adenocarcinoma (DPAC). We found that nuclear expression can be detected approximately 50% DPAC. Blockade by stable shRNA-mediated knockdown showed no effects on cell growth vitro. However, inhibition motility even response to stimulation epidermal or interleukin-6. These findings were paralleled a reduction prometastatic proangiogenic factors Subsequent vivo experiments revealed strong blockade subcutaneous orthotopic models. impaired angiogenesis vivo. In contrast model, model proliferation emphasizes meaning assessing targets appropriate microenvironment. Taken together, our results suggest potential for