SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.
作者： T Inoue , M Hiratsuka , M Osaki , H Yamada , I Kishimoto
关键词: SIRT2 、 Cell cycle 、 Biology 、 Mitosis 、 Metaphase 、 Microtubule 、 Premature chromosome condensation 、 Endoreduplication 、 Cyclin B 、 Cancer research
摘要: … Our results suggest that SIRT2 NAD-dependent tubulin deacetylase activity is required for its function. Acetylated tubulin is abundant in stable microtubules but it is absent from dynamic …
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