Efectos de la introducción progresiva de los inhibidores de la calcineurina en la función renal de una cohorte de pacientes que recibieron trasplante de hígado Effects of progressive introduction of calcineurin inhibitors on the renal function of a cohort of liver transplant recipients

摘要: Background: acute renal disease (ARD) occurs in liver transplantation with an incidence ranging from 12 to 64%, associated hospital mortality of 40 67%.This study used the RIFLE criteria analyze effect immunosuppressive regime including calcineurin inhibitors (CNi) development ARD patients transplantation. It also assesses protocol and progressive late introduction CNi as a strategy reduce posttransplant Methods: cohort analytic 163 Results: met inclusion average age 51 (46-56) years. Of these patients, only 11 (6.74%) had Cyclosporine was administered 126 (77.3%) tacrolimus transplant 21 (12.88%). Immediately after transplant, were classified into two groups: high risk developing ERA without kidney problems. At first they introduced CNI third day last six 18 hours dose that gradually increased Conclusions: gradual could be effective (Acta Med Colomb 2011; 36: 130-134).