Alterations of cell cycle regulators in localized synovial sarcoma: A multifactorial study with prognostic implications.

摘要: Genetic alterations of cell cycle regulators are thought to represent uncommon and possible secondary events in sarcomas characterized by recurrent chromosomal translocations. The present study investigates this hypothesis on synovial sarcoma (SS), assessing the frequency expression clinical implications detecting critical regulatory proteins. A homogeneous cohort 49 patients with localized SS, restricted extremity available long-term follow-up information, was selected from our files. We focused molecules involved G1 checkpoint G1-S transition, including cyclins D1 E, p21WAF1, p27Kip1, mdm2, p53, Ki67. cutoff point 10% immunoreactive tumor nuclei define a positive phenotype for any given marker, except High Ki67 proliferative index considered when ≥20% cells displayed nuclear immunoreactivity. Biphasic SS were analyzed, taking into account separately these proteins spindle glandular components. Disease specific survival modeled using Kaplan-Meier method log rank test Cox regression. analyzed included 23 females 26 males, histological type distribution 35 monophasic 14 biphasic SS. median survivors 53 months, 5-year disease-specific 63% metastatic disease-free 40%. phenotypes identified different markers studied as follows: cyclin D1, 59%; 29%; p21, 51%; p27, 69%; 16%; Ki67, 59%. observed that high correlated survival, but only p53 independent variables prognostication. suggests more common than originally thought. overexpression could be use marker together index, identifying subset increased risk relapse.