The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma.

摘要: Recently a T to C substitution in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD) gene was observed that changes amino acid protein from valine (V) alanine (A) and is associated with decreased defense capacity against oxidative stress. We investigated whether this polymorphism MnSOD increased risk for colorectal cancer among Hispanics non-Hispanic whites. All controls (63 Hispanic, 58 non-Hispanic) cases (64 61 were genotyped using fluorogenic 5'-nuclease assay. The frequency 0.62 disease-free 0.51 whites controls. No significant differences between patients either ethnic group (p=0.90) excluding as factor Among Hispanic individuals allele more frequently young patients. Patients homozygous (24/64) showed mean age 37.6 years compared 42.3 heterozygotes (29/64) 48.4 V (p=0.045, ANOVA). data demonstrate -9Val/-9Ala common than Furthermore, suggest may be an develop at Hispanics.