Effects of Red-Cell Storage Duration on Patients Undergoing Cardiac Surgery
作者： Marie E. Steiner , Paul M. Ness , Susan F. Assmann , Darrell J. Triulzi , Steven R. Sloan
关键词: Surgery 、 Proportional hazards model 、 Organ dysfunction 、 Medicine 、 Severity of illness 、 Adverse effect 、 Intention-to-treat analysis 、 Observational study 、 Cardiac surgery 、 Randomized controlled trial
摘要: BackgroundSome observational studies have reported that transfusion of red-cell units been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoingcardiac surgery may be especially vulnerable the effects transfusion. MethodsWe conducted a randomized trial at multiple sites from 2010 2014. Participants 12 years age or older who were undergoing complex cardiac and likely undergo red cells randomly assigned receive leukocyte-reduced 10 days less (shorter-term storage group) 21 (longer-term all intraoperative postoperative transfusions. The primary outcome was change in Multiple Organ Dysfunction Score (MODS; range, 0 24, higher scores indicating severe organ dysfunction) preoperative score highest composite through day 7 time death discharge. ResultsThe median tim...
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