Natural Killer Cell Function in Human Lung Is Compartmentalized1–3

摘要: Natural killer (NK) cells are a subpopulation of lymphocytes capable killing variety neoplastic targets. NK can limit pulmonary metastases in animal models and could be important mediators tumor defense human lung. Previous studies humans have suggested, however, that obtained by bronchoalveolar lavage (BAL) functionally inert. We purified from lung tissue compared the activity these with peripheral blood. The minced whole specimens was comparable to found Monoclonal antibodies 2 markers on blood large granular (LGL) were utilized determine phenotype cells. Lymphocytes expressing Leu 11b responsible for as all function abrogated pretreatment anti-Leu complement. In contrast, 7 had little activity. Although the...