Kinetic Modelling for the Assay of Nortriptyline Hydrochloride Using Potassium Permanganate as Oxidant

摘要: Kinetic methods for accurate determination of nortriptyline hydrochloride have been described. The are based on the oxidation with KMnO4 in acidic and basic media. In medium, decrease absorbance at 525.5 nm increase 608.5 were measured as a function time. variables affecting reactions carefully investigated optimised. models such initial rate, rate constant, variable time fixed employed to construct calibration curves. selected quantification hydrochloride. curves showed linear response over concentration range 10–50 μg mL−1 10–60 method (2 min). graphs 10–100 (4 limits detection min) 1.02 3.26 mL−1, respectively. found be 1.67 1.55 min), successfully applied commercial dosage form. Statistical comparison results proposed those reference exhibited excellent agreement there is no significant difference between compared terms accuracy precision.